Working together


ian nabney

June 21st, 2010

Probability theory may sound like arcane and irrelevant mathematics, but it’s the stuff that enables us to work with uncertainty. Imagine a random event such as a heart attack, something that rarely happens but when it does, it has devastating effects. It’d be helpful if we could work out just how likely such an event would be without having to take up the time and resources of expert cardiologists.

Ian Nabney, a Professor of Computer Science at Aston University, works with modern computing power which vastly expands the range of problems that can be tackled. Couple probability theory with machine learning (the design and development of algorithms that allow computers to evolve behaviors based on empirical data, such as from sensor data or databases), for example, and, he says, we can put a lot of the decision-making expertise and power of the best of cardiologists on a ‘box’ can be used by a non-expert.

Professor Nabney is a member of Aston’s Non-linearity and Complexity Research Group and his research is in pattern analysis.  He specialises in developing applications with industrial and medical partners in such areas as data visualisation, energy price forecasting, and probabilistic models of risk in jet engine design.  His software toolbox, Netlab, has over thirty-five thousand users around the world, and can be downloaded here; see also his book NETLAB: Algorithms for Pattern Recognition.

jayne franklyn

June 21st, 2010

Evidence-based medicine has at its foundation high quality clinical research.

Take, for example, some of the most common diseases afflicting 21st century populations in affluent societies — hypertension, obsity and a wide range of autoimmune diseases such as rheumatoid arthritis, Type 1 diabetes and thyroid diseases.

This last set of diseases is the particular research area of Professor Jayne Franklyn, one of the world’s authorities on thyroid disorders. All of these diseases, she says, are so-called ‘polygenic disorders‘. Investigations now enabled by number-crunching of vast datasets on many thousands of patients with these common diseases allows us to determine the relative contribution of minor variations in DNA structure. We can thereby assess the risk of people likely to suffer from them and, where we can, take preventative steps.

Jayne Franklin is Professor of Medicine and Head of School of Clinical and Experimental Medicine at the University of Birmingham. She’s also Consultant Endocrinologist, University Hospitals Birmingham NHS Trust.

Her laboratory and clinical research interests focussing on the pathogenesis of thyroid cancer and autoimmune thyroid disease and the effects of subclinical thyroid dysfunction.

She’s a Fellow of the Academy of Medical Sciences, and American Thyroid Association Paul Starr Lecturer. She was awarded the Royal College of Physicians Goulstonian Lectureship in 1994, as well as Plenary Lectureships of the Society for Endocrinology, Clinical Endocrinology Trust, and the International Congress of Endocrinology.

As well as being Head of the School of Clinical and Experimental Medicine at the University of Birmingham she an active teacher and researcher, with over 200 peer reviewed papers in thyroid research.

elizabeth wellington

June 21st, 2010

Professor Elizabeth Wellington asks a pertinent question in these times of swingeing cuts in universities. Are we training enough young scientists for the future?

She is in no doubt of the calibre of youngsters coming up, nor of the importance of the work they can do. Moreoever for the first time in her career, she’s noticing productive collaborations between biologists and physical scientists ranging from soil scientists to mathematicians and engineers, a trend that can only continue and to great beneficial effect. There are wide-ranging aspects of particular problems that need addressing.

But the question remains: Are we training enough of young scientists for the future?

Professor Liz Wellington is an environmental microbiologist, and has been involved in ecological research and soil microbiology for over 20 years. With a personal Chair, she is part of the Microbiology section within the Department of Biological Sciences at Warwick University, and was co-director of the Warwick Systems Biology Centre (2007-07) to co-ordinate interdisciplinary research allowing biological systems to be modelled. Her current research focuses on the fate of bacterial pathogens in the environment and understanding the functional properties of soil bacteria.


jon preece

June 21st, 2010

Sir John Beddington, the UK Government Scientific Adviser, has chillingly said:

Can nine billion people be fed? Can we cope with the demands in the future on water? Can we provide enough energy? . . . And can we do all that in 21 years time? That’s when things are going to start hitting in a really big way . . . 2030 is not very far away.

Over the next few decades there will tremendous advances made in nanotechnology, Professor Jon Preece‘s research area.

But that’s not the reason why he’s optimistic about science and scientific endeavour. The challenges we’re facing require a multidisciplinary approach. What Professor Preece is optimistic about, even in the face of the challenges Sir John Beddington calls the ‘perfect storm’, is the way scientists, medics, engineers from all backgrounds are not afraid to speak to each other, to exchange ideas and concepts, to bring new perspectives on old problems, to work together to create innovative and transformative solutions that will have the potential to solve the pressing, serious problems we’re facing.

Jon Preece is Professor of Nanoscale Chemistry at the University of Birmingham. His work is focused on the interdisciplinary nature of nanoscale chemistry, including nanostructuring surfaces via the integration of top-down and bottom-up methodologies, gene delivery based on polycations, nanotribology, liquid crystals and nanoscale electronics. He is also on the Editorial Board of the Chemistry Society Reviews.

laura green

June 21st, 2010

Scientists may spend a lot of time thinking, but their thoughts — and their actions — are always grounded in a very real practicality. And perhaps none more evidently so than scientists engaged in the production of food from farmed animals.

Think of the breathing, watchful bulk of cows grazing, for example, or the gregarious grunt-snuffles of pigs at the trough, or white-blobs-on-fells that turn out when closer to be sheep. Professor Laura Green‘s aim is to reduce clinical impact of endemic infectious diseases of farmed animals such as these, knowing we can further our understanding of infectious disease processes through data collection, careful analysis, modeling and interpretation in a biological framework.

Gone are the days when we believed we could produce low cost food at any price, including poor animal health. It’s now possible to monitor, for example, a dairy cow all its life. And the sheer volume of data such monitoring from so many sources is overwhelming.

This means moving from a reductionist approach for researchers such as Professor Green, to an assimilatory one. With developments in communication, data capture, storage and processing, it will be possible to address increasingly complex problems; see, for example, the Lame Cow Project she’s involved in.

Professor Laura Green is an epidemiologist in the Department of Biological Sciences at Warwick University. She leads multidisciplinary teams to reduce the clinical impact of endemic infectious diseases of farmed animals.  Of current interest are three research projects  on the control of footrot in sheep; one combines laboratory studies of persistence of D. nodosus, the causal organism, and mathematical modeling of persistence, one is investigating a novel approach to treatment and control in a clinical trial and one is on technology transfer to the sheep industry.

For all research work at Warwick University on infectious disease epidemiology of livestock, including foot and mouth, see here.

jim tucker

June 21st, 2010

Chemistry is a discipline that underpins many others. It has a vital role to play, says Jim Tucker, Reader in Supramolecular Chemistry at the University of Birmingham, in the synthesis and study of new materials, drugs and therapies, energy conversion and storage, solar energy and diagnostics for human health . . .

Dr Tucker studied for his BSc and PhD in Chemistry at Kings College, London. After post-doc work in Japan and France, he was Lecturer in Inorganic Chemistry at Exeter before moving in 2005 to his present position at Birmingham University where he is Reader in Supramolecular Chemistry and currently holds an EPSRC Leadership Fellowship.

ann vernallis

June 21st, 2010

Dr Ann Vernallis studies small proteins called cytokines. Although most people will never have heard of them, abnormal increases or decreases in cytokine levels are associated with a variety of diseases. Researchers have been interested in them for years; medical interest really took off when anti-TNF (tumour necrosis factor) treatment was developed for rheumatoid arthritis — an example of the beneficial interplay of basic and clinical sciences.

Dr Ann Vernallis is a Lecturer in the School of Life and Health Sciences at the University of Aston. She’s interested in cell signalling. As a post-doctoral fellow, she studied cytokine receptor interactions in the IL-6 family. At Aston, she’s studied the secretion of Leukemia Inhibitory Factor (LIF), the pro-inflammatory activities of lipoteichoic acid from Gram-positive bacteria and cytokine levels in patients with infections. She’s currently working on the anti-inflammatory effects of tetracyclines, and she collaborates on studies of neuron/astrocyte interactions in a neuronal stem cell model.

graham anderson

June 21st, 2010

Just how do your cells know what’s particularly you and what’s not-you? How, for all of us, do our cells discriminate between self and non-self?

Or, to put it into the more formal language of immunologists, what is the spectrum of antigens recognised by the peripheral T-cell population?

Such is the important work of Professor Graham Anderson in the School of Immunity and Infection at the University of Birmingham. And it’s complex work, requiring the input from a variety of disciplines, and from clinicians as well as pure researchers — Professor Anderson, for example, monitors how designer organs function in an in vivo setting.

In The New Optimists, Professor Anderson makes the point that it’s this very sociability of science and scientists that leads to a sharing of ideas, a key driver in developing scientific understanding.

elizabeth oliver-jones

June 21st, 2010

The case for blue skies research is made passionately by Elizabeth Oliver-Jones in The New Optimists, and with due cause. Her particular research focuses around the study of early cell interactions in amphibians, about the little-known molecular mechanisms by which vertebrate embryos achieve the myriad complex patterns and cell types found in the adult animal.

Such work may seem a far cry from most of our lives, perhaps something even for the politician’s knife. But (and this is a big BUT), such seemingly esoteric research by Professor Oliver-Jones and other scientists on the Xenopus (a type of aquatic frog native to sub-Saharan Africa) has established gene expression and function in a number of human diseases such as colorectal cancer, and has also provided biochemical insight into important oncogenes. Indeed, her work on amphibians is important in understanding cell signalling, and in the relationships between genes and development in many other living organisms including ourselves.

Elizabeth Oliver-Jones is a Professor in the Department of Biological Sciences at the University of Warwick. Her work is funded by the BBRSC and the Wellcome Trust, including £1.5M from the Wellcome Trust for a Xenopus Stock Centre, 2006-2011 with Dr Matt Guile at the University of Portsmouth.

deirdre kelly

June 21st, 2010

Difficult, complex operations such as liver transplantation have not only become safe but routine as a result of a combination of blue sky scientific research and clinical science. As a Director of the National Liver Unit at Birmingham Children’s Hospital and Professor of Paediatric Heptology at the University of Birmingham, Deirdre Kelly is at the centre of such world-class translational medicine.

In The New Optimists, she also makes the point that complex questions about the mechanisms of the disease and any genetic basis of disease demands sophisticated collaborations between experts to maximise success.

Professor Kelly is a graduate of Trinity College, Dublin. She has trained in both adult and paediatric gastroenterology and hepatology. She set up the Paediatric Liver Unit at Birmingham Children’s Hospital which provides a national and international service for children with liver failure and undergoing liver transplantation, transforming survival and outcome for these children. Until 2008, the Unit was the only national unit to be designated for small bowel and liver transplantation in the UK.

She runs an active research programme focussing on viral hepatitis in children, molecular biology and genetics of inherited liver disease, quality and outcome of life following liver and/or intestinal transplantation. 
She is a Commissioner on the Care Quality Commission (2008-).  She is currently President of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).  She was Chairman of the Lunar Society (2007-2009).

She is also Editor of Diseases of the Liver and Biliary System in Children, 3rd edition (2008) Wiley-Blackwell.