Posts Tagged ‘molecular medicine’

robin may

June 19th, 2010

In his contribution to The New Optimists, Robin May, a Senior Lecturer in Infectious Disease in the School of Biosciences at the University of Birmingham, and Director of the May Lab, makes an assertion astounding  to Jenny Uglow who wrote the Foreword to the book; namely, that we’re about to enter an age when having a copy of one’s own genome sequence is as common as carrying a mobile phone is today.

The implications of having the availability of whole genome sequences will usher in an era of truly ‘personal’ medicine, and will shake our understanding of who we really are.

At the May Lab, scientists carry out work to know more about the continual struggle between pathogens and their hosts. This struggle is a major selective force, resulting in the evolution of ever more complex host-pathogen interactions as both sides attempt to ‘win’ the conflict. Scientists here are interested in the molecular basis of such interactions and in how they have evolved.

michael overduin

June 19th, 2010

We can now number of genes, proteins and cells, and we can see their individual shapes in motion. One of the greatest opportunities in biomedical research today is to understand how these various jigsaw bits fit together. Currently, however, says structural biologist Michael Overduin, we have little idea of what the individual jobs are of each protein produced by our genes.

His work is to find this out, using computer programmes which scan the surface of each protein and predicts whether it can interact with membranes, proteins or small molecules.

Professor Michael Overduin is Professor of Structural Biology art the University of Birmingham. His research team solve the structures or proteins involved in cancer and infection in NMR Facility in the Henry Wellcome Building.(note: NMR is the abbreviation for nuclear magnetic resonance.)

This HWB•NMR is the UK’s largest NMR facility, providing academic and industrial users with open access to six NMR spectrometers operating at 500-900 MHz, four cryogenic probes and high throughput autosamplers.

jon frampton

June 19th, 2010

The application of our rapidly expanding knowledge about stem cells will revolutionise the future of medicine, says Jon Frampton, Professor of Stem Cell Biology and Director of the Stem Cell Centre at the University of Birmingham.

His Centre covers a wide range of research areas from neural stem cells, skeletal muscle stem cells, tooth stem cells and germ cells derived from embryonic stem cells to studies on 3D materials for tissue engineering.  Complementing these research efforts, the Centre also includes a number of members of the School of Social Sciences who help to provide a broad perspective on social and ethical issues associated with stem cell research.

Of his own major research interests, Professor Frampton focuses on the regulation of stem cell behaviour in health and disease.  In particular, I am interested in blood stem cells, both normal and those related to leukaemia, although other studies encompass a number of adult stem cell types, for example, those giving rise to bone and fat and the resident stem cells in the heart.

Before coming to Birmingham, he ran research groups in the European Molecular Biology Laboratory in Heidelberg (1988-1995) and the Weatherall Institute of Molecular Medicine at the University of Oxford (1995-2002).